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In the Metformin in Gestational Diabetes (MiG) trial published in 2008, in which patients were randomized to insulin versus metformin, there was a signal that there was an increased risk for elevated BMI and childhood overweight later in life at age 7 to 9 years in one of the cohorts

Insulin is responsible for the way our bodies break down, store, or utilize fat

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It is also conceivable that enzymatic action might greatly accelerate HDX rates

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The investigators compared people who had used these drugs with clinically similar patients who had not received them, then assessed whether either group was more or less likely to develop substance use disorders